|
KMID : 1191520150200010081
|
|
Journal of Korean Traditional Oncology
2015 Volume.20 No. 1 p.81 ~ p.88
|
|
|
Current state and prospective of the Korean medical research on the cancer metabolism
|
|
Chung Tae-Wook
Kim Eun-Young
Choi Hee-Jin
Choi Hee-Jung
Ha Ki-Tae
|
|
|
Abstract
|
|
|
|
Generally, normal cells synthesize adenosine triphosphate (ATP) through oxidative phosphorylation in the mitochondria. However, they produce ATP through lactic acid fermentation on hypoxic condition. Interestingly, many cancer cells rely on aerobic glycolysis for ATP generation instead of mitochondrial oxidative phosphorylation, which is termed as "Warburg effect". According to results from recent researches on differences of cancer cell metabolism from normal cell metabolism and because chemotherapy to suppress rapidly growing cells, as a side effect of cancer treatment, can still target healthy cells, there is merit in the development of small-molecule inhibitors targeting metabolic enzymes such as pyruvate dehydrogenase kinase (PDHK), lactate dehydrogenase (LDH) and monocarboxylate transporter (MCT). For new anticancer therapy, in this review, we show recent advances in study on cancer cell metabolism and molecules targeting metabolic enzymes which are importantly associated with cancer metabolism for cancer therapy. Furthermore, we would also like to emphasize the necessity of development of molecules targeting metabolic enzymes using herbal medicines and their constituents for anticancer drugs.
|
|
|
KEYWORD
|
|
|
Cancer metabolism , Warburg effect , lactate , Korean medicine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|
|